Side Effects of Pyrethroid and Supporting Role of Onion in the Male Rat's Spermatogenesis

To the Editor: Permethrin is a great handmade of chemical agents, pyrethroid Type I, which exists in two main isomers, Cis and Trans.[1] Its application in farming and building is due to well availability and repelling of pests. It may be easy absorbed from the gastrointestinal and skin tract and by inhalation of dust.[2,3] They are great chemicals with high producing of reactive oxygen species and inducer of necrosis pathway. Inadequate information of using permethrin resulted in many side effects on biological systems. Spermatogenesis is one of the main vital systems susceptible to reactive oxygen species and oxidative stress.[4] Since spermatogenesis takes place in the testis, any chemical agent like permethrin could be destroyed cellular structure and function and leads to infertility.[5] On the other hand, done studies for confronting these effects were mostly focused on reducing infertility rate and proposing the best way to treatment. Most studies represent a varied range of antioxidants to solving male infertility. Allium cepa (onion), a natural antioxidant, was used in traditional medicine. It protects DNA and other important molecules from oxidative stress and improves sperm parameters, so leads to increase fertility rate.[6]